Recent trends to overcome Klebsiella pneumoniae infections In the intensive care units

Articles in Press

Document Type : Review Article

Authors

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Tanta University, Tanta, Egypt

Abstract

Background: Klebsiella pneumoniae is an opportunistic pathogen that frequently causes nosocomial infections and contributes to significant morbidity and mortality. Numerous factors are believed to be associated with the colonization of K. pneumoniae in hospital and community settings. K. pneumoniae frequently colonizes hospitalized individuals, leading to extraintestinal diseases like bloodstream infections (septicemia), urinary tract infections, and pneumonia. Patients in intensive care units (ICUs) are especially vulnerable to such infections. Infections with K. pneumoniae are particularly problematic in the healthcare setting for newborns, elderly, and people with impaired immune systems. Due to the severity of the diseases, resistance to numerous antibiotics, and difficulty of treatment, K. pneumoniae has drawn the interest of researchers worldwide in recent years. K. pneumoniae is a significant global antibiotic resistance source and transmitter. The global rise in resistance highlights the need for novel therapeutic options. The choice of an appropriate antibiotic for hospital-acquired infections is becoming a rising global issue due to this resistance. In this review, we reveal that K. pneumoniae is a major threat to patients in intensive care units and we discuss the mechanisms of drug resistance in K. pneumoniae. We demonstrate the mechanisms and effects of emerging novel therapeutic strategies for K. pneumoniae in recent years to overcome drug resistance in the treatment of K. pneumoniae infections for better future.

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Main Subjects

Microbes and Infectious Diseases

Articles in Press, Accepted Manuscript
Available Online from 27 January 2025

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